Diffusive non-tumoral pathology of the breast: current state of the problem. Diagnosis and treatment of mastalgia

In the twentieth century, a whole teaching of mastopathy was formed. However, over time, accumulated data have questioned existence as separate nosological form, because term “fibrocystic disease” while mastalgia is most common symptom does not correspond to holistic concept disease. This “disease” can be diagnosed in any woman and more or less successfully treated. United States, this obsolete 1985. Instead, ANDI (Aberrations Normal Development Involution breast) proposed, which correctly corresponds pathogenesis. Leading guidelines on management benign diseases breast now use term. Therefore, treatment necessary only for very limited number patients. Cyclic required therapeutic intervention, cases classified “disorder” according classification. There are following types that require medical intervention: cyclic, non-cyclic, extramammary. Homogeneous evidence has been obtained favor antigonadotropins, dopamine agonists, selective estrogen receptor modulators, gonadotropic releasing hormone agonists among non-surgical methods cyclic mastalgia.A numerous studies shown Vitex agnus castus reduce pain discomfort patients with its effects compared bromocriptine cabergoline. The European Medicines Agency recognized extract, by extraction ethanol 60% (Prefemin), extract status “widespread use” premenstrual syndrome. Prefemin well studied, efficacy safety, satisfactory long-term tolerability proven clinical trials evidenced A. preparation high dosage considered drug choice